When the antibiotic valinomycin is added to actively respiring mitochondria, several things happen: the yield of ATP decreases,

Question

2 months ago

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When the antibiotic valinomycin is added to actively respiring mitochondria, several things happen: the yield of ATP decreases,

the rate of O2 consumption increases, heat is released, and the pH gradient across the inner mitochondrial membrane increases. Explain these observations by listing the causal order of events that occur beginning with the addition of valinomycin to the respiring mitochondria and ending with the release of heat. Note: some events listed do not occur and should not be placed Valinomycin added The rate of ATP synthesis decreases The rate of electron transfer and oxygen consumption increases The pH gradient across the The valinomycin-K complex moves K ion out of the mitochondrial matrix. The electrical potential across the The rate of ATP hydrolysis increases The electrical potential across the mitochondrial membrane decreases. Valinomycin binds K" ion. The valinomycin-K' complex moves into the mitochondrial matrix. The pH t across the Heat released

Biology

2 answers:

lana [2.4K] · Answer 1 · 2026-03-14T11:37:54+03:00

Answer:

An illustration of UNCOPLERS is valinomycin.

Typically, uncouplers disrupt the connection between the electron transport chain and the oxidative phosphorylation process involving ADP... Consequently, ATP production halts. The vancomycin-K complex obstructs ATP formation by interfering with the proton motive force that provides the energy necessary for ADP to convert into ATP

◼When valinomycin is introduced

◼It binds with K" ion.

◼The valinomycin-K' complex penetrates the mitochondrial matrix.

◼There is a reduction in the electrical potential across the mitochondrial membrane

◼ATP synthesis slows down

◼The rate of oxygen consumption and electron transfer accelerates.

◼The valinomycin-K complex expels K ion from the mitochondrial matrix.

◼This leads to a decrease in pH and an increase in heat output.

vlada-n [2.5K] · Answer 2 · 2026-03-14T11:40:37+03:00

Response:

The question is lacking certain details, and I have included the complete question in the request for further information section. Since this inquiry pertains to outlining a process, I have outlined steps for enhanced comprehension.

Clarification:

INITIAL STEP 1

Adding valinomycin

STEP 2

Valinomycin binds with K+ ion

STEP 3

The electrical potential across the mitochondrial membrane diminishes

STEP 4

ATP hydrolysis rate escalates

STEP 5

ATP synthesis rate declines

STEP 6

The pH difference across the mitochondrial membrane surges

STEP 7

The electrical potential across the mitochondrial membrane lessens

STEP 8

The valinomycin-K+ complex can now move into the mitochondrial matrix

STEP 9

The valinomycin-K complex transfers K+ ion out of the mitochondrial matrix

STEP 10

Electron transfer and O2 consumption rates increase

FINAL STEP

Generation of heat