Biotic refers to living entities, while abiotic denotes non-living ones.
The variations caused by genetic modification lead to alterations in the organism's genome. Such changes express traits in ways that differ from the typical. These variations can cause genetic mutations that may be passed down generations.
In the case of sexual reproduction, the organism's genome remains unchanged. Here, only an exchange occurs between the alleles inherited from each parent, and this does not result in mutations.
Mary initially saw a doctor who wasn't trained in drawing blood or taking x-rays. She subsequently visited a different place that specializes in those procedures.